THCP and CBDP – firebird-cbdoil
As the demand for cannabis research reaches unprecedented heights, it is becoming more evident than ever that this is a much more complex plant than we could ever have imagined.
Modern cannabis research dates back to the early 1960s when Israeli professor Raphael Mechoulam isolated the very first phytocannabinoid, THC. It was during this time that the CBD was fully elucidated for the first time, although it was discovered 20 years earlier. Almost 150 phytocannabinoids have been discovered since then, although the list of compounds to be isolated and investigated is still short.
What we have also discovered over the years is that different versions of the same cannabinoid can exist. For example THCA vs THC. The only difference between these two cannabinoids is that THCA still has a carboxylic acid group, which means that it is only present in raw material that has not yet been exposed to high temperatures. As soon as a cannabis bud is smoked or vaporized, the THCA loses this carboxylic acid and becomes THC. The same connection exists between the CBDA and the CBD.
Thanks to an analysis technique known as mass spectrometry, the identification of new cannabinoids is becoming increasingly easier. A group of Italian researchers who are very familiar with this process recently published a study that introduced two new cannabinoids that still need to be discussed: THCP and CBDP. But what exactly are these new connections on the block and what does it mean for patients, consumers and industry players?
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What is THCP?
Let's start with the basics, THCP stands for tetrahydrocannabiphorol and, as expected, has a molecular structure similar to THC. However, there is one crucial difference: it has an elongated alkyl side chain with seven carbon bonds, compared to only 5 bonds in the regular THC side chain.
Look at the picture below. The zigzag line that extends out of the cell structure is the side chain. Every point on this line, including the very last point at the end of the line, is a link. As you can see, both THCP and CBDP have 7 links in their chain, whereas THC and CBD have only 5 links in their side chain.
Now you may be wondering why this is so important. Well, this one
are the first cannabinoids with side chains longer than five links and length
the side chain has been shown to play an important role in the interaction of THC
with the body's CB1 receptors. Basically, the elongated side chain does that
Binding affinity between cannabinoid and receptor much stronger.
Researchers checked the binding affinity of THCP
CB1 and CB2 receptors and found an impact on both. When it came to the CB1
THCP receptor was 33 times more active than normal THC. With the CB2
THCP receptor was about 5-10 times more active.
More information about the endocannabinoid system can be found here. You can also learn about anandamide here.
What is CBDP?
Just like THCP, CBDP (cannabidiphorol) has a longer side
Chain as its counterpart. However, since CBD has a poor binding affinity
CB receptors, researchers are not sure if this disclosure means anything. because
Studies on the medical potential of the CBDP are currently not a priority.
It is possible that this longer side chain improves the binding of the cannabinoid to these receptors, but this still has to be known. There is also the question of the entourage effect. Because it is known that a little THC can enhance the effects of CBD. Can THCP have the same effects? As the researchers emphasize, science can be full of surprises.
What are the medical effects of these new cannabinoids?
As already mentioned, it is not known whether CBDP has one
additional therapeutic value at all. However, THCP should be
the next big thing in medical cannabis research. When it comes to THC, a minimum
3 links are required to bind the cannabinoid to a receptor. Scientists have
The binding affinity was found to peak at eight links and then decrease.
and THCP is closer to this binding peak than any other cannabinoid discovered
This means that all medical effects that users experience
of THC, such as pain and nausea relief, neuroprotective benefits and
more, can be greatly increased by adding the THCP cannabinoid. It is essentially
A booster for THC that increases the effects on the body many times over.
It is also interesting about THCP that we are still not
sure if THCP is psychoactive at all. Logically, one would assume that because it is so
"Stronger" than THC, but would also have stronger psychotropic effects
That is not necessarily the case. A slight change in the molecular structure could also cause this
greatly change the way we feel the effects of this cannabinoid
Can I find THCP anywhere?
At the moment it is difficult to find THCP
Products or varieties in your local pharmacies or even online stores. If that
Connection proves to be just as important, as researchers currently estimate, in addition
Studies, processing and cannabinoid-specific growing techniques will be used
required to produce THCP in a substance that can actually be bought and consumed.
Apart from the obvious extractions that THCP oil can produce,
Capsules and more really emphasized the need to cultivate breeds
Cannabis and hemp that do not dominate THC or CBD. We are already learning
more about spots that contain higher levels of CBG, THCV and CBDV, i.e. flowers
with additional connections is also becoming more popular.
According to the study, the researchers will continue to test the THCP cannabinoid, perhaps even CBDP, to see how it works in the human body and what conditions can be treated with it.
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Post researchers discover two new cannabinoids: THCP and CBDP first appeared in CBD testers.