Can You Be Immune To Meals? – firebird-cbdoil
"Why don't I work with groceries?"
Consuming cannabis through food has many advantages. Edibles are stronger than smoking, they last longer and are much more discreet on the go. For some, cannabis foods just don't work.
"Why don't my groceries work?" … "I tried food and felt nothing." … "I ate 500 mg THC, why don't I feel high?"
These are the questions I keep hearing from frustrated patients who then ask, "Can you be immune to food?" The answer is yes. In certain circumstances, the body is unable to absorb and process orally consumed cannabinoids.
Food is processed differently than smoking
The mantra in the cannabis industry is to start low and go slowly. This means that you start with a low dose and slowly and gradually increase the dose over time. Especially when it comes to food.
This is because orally consumed cannabinoids (such as THC and CBD) are processed differently than inhaled cannabinoids. First, keep in mind that cannabinoids are lipophilic, behave very much like fats, and are often given in addition to fat to improve absorption (i.e. butter, oil, etc.). The body processes them similarly to other lipids.
When you eat edible cannabis, it has to travel through the digestive system, where the food is broken down and the cannabinoids are absorbed. After absorption, they migrate through the blood to the liver, where enzymes convert the cannabinoids into metabolites. The metabolites then migrate to the brain and this is when the consumer begins to feel the effects. This process can take hours.
This means that the body takes much longer to process food than when inhaling. While the effects of inhalation can be felt immediately, it can take HOURS to start working. Most patients report that it takes 20 minutes to four hours for the food to start working.
Due to the different metabolic processes, foods are usually much stronger than smoking. This means that consumers typically need a much lower dose of food compared to the dose they would need if they smoked. In addition, food lasts much longer than inhalation. Some patients report effects lasting 6-8 hours.
The metabolic process for processing orally consumed cannabis is also complex. After the body has finally absorbed the cannabinoids, they need to be processed.
Cannabinoids are processed via the CYP450 pathway, and this process is very complex. A variety of problems can affect the production of metabolic enzymes. If a person lacks an effective amount of the required enzymes, they may not be able to fully metabolize orally administered cannabis. The effects also depend on the concentration and availability of endocannabinoid receptors, which can vary from person to person.
The Prof of Pot offers an excellent explanation for cannabinoid metabolism.
It could be genetic
In addition, there is a very strong genetic component that influences cannabis metabolism.
These genetic components are the reason why everyone reacts so differently to cannabis. Some people are considered fast cannabis metabolizers, while others are considered extremely slow metabolizers.
How your body processes cannabis could be genetic.
What to do if food doesn't work for you?
Note that absorption and metabolism can change depending on a variety of factors. This means that the quality of your absorption can vary. This means that one day, foods may feel more effective than others.
One factor that can affect absorption is what you ate at the time of consumption. Taking food with a full stomach against an empty stomach can lead to different results.
Cannabis experts have traditionally advised patients to consume cannabinoids when accompanied by fat, but this advice can be counterproductive for anyone who has problems with fat absorption.
Most foods are made with a lipid base like oil. Occasionally, patients who have problems with traditional lipid-based products are more fortunate with products that have been extracted with alcohol or infused into vegetable glycerin.
Cannabis tinctures made from alcohol or vegetable glycerin can also be used sublingually. This means that the cannabinoids are absorbed by the mucous membranes under the tongue. This may offer a discrete method of administration, but keep in mind that true sublingual administration is metabolized much like smoking and therefore does not offer the long-term effects that food has.
As always, if one product doesn't work, try another. And remember that every cannabis strain can cause a different reaction.
Some people have fantastic results with cannabis foods, while others cannot use foods at all. The uptake and metabolism of orally consumed cannabinoids are complex. Chronic health conditions, metabolic problems, medication and genes can have a significant impact on how a patient processes food. Edibles don't work for everyone, luckily there are many other methods of consumption.
When making cannabis foods at home, proper decarboxylation is essential. This video explains more: