Extremely-Low Hashish Dosage: When Microdosing Is Nonetheless Too Excessive


Emma Stone June 8, 2020

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<p> If you are ready to drink coffee or drink low-alcohol beer, the idea of ​​reducing your cannabis dose is probably welcome. Not surprisingly, today's cannabis users generally don't try to be stoned to paralysis. But Pot has never been as strong as it is today. According to a <span style= 2019 study the mean Δ9-THC concentration in cannabis has almost doubled in the past ten years, from 8.9% in 2008 to 17.1% in 2017.

Instead of resigning to confusing head heights, consumers are experimenting with novel methods to get the most out of their hit, with less … one hit. As growing research confirms that a little weed travels a long way, both cannasseurs and researchers are trying to improve the positive results of cannabis and minimize harmful ones with very low doses.

Variations on the subject of microdosing

The concept of lightening the load is not new. Microdosing a drug development process to assess the effects of a tiny dose of a substance on the body first became popular a few years ago and was incorporated into cannabis culture. Smart consumers became aware of the benefits of small doses that had therapeutic benefits without fear or paranoia. Microdosing also enables the curious Canna to dip their toes in the water.

While microdosing is a method to provide a more informed cannabis experience, other variations have emerged – "Lite" products that inexperienced consumers can experience the joys of weeds without their potential pitfalls. With the Rookie Cookie with 10 mg CBD and 10 mg THC, for example, you can tear off an entire cookie, enjoy the enthusiasm and stay clear enough to work.

Similar to CBD oil, marijuana lite products promote the feeling of relaxation or a body high without a head up. The most critical thing is that they make guesswork when dosing food easier, so that it is no longer necessary to cut an infused bar of chocolate into twenty pieces.

Italy has even witnessed the meteoric rise of a movement " Cannabis Light ". C annabis light that became legal in December 2019, refers to cannabis sativa plant derivatives with levels of 0.6% THC or less, which is super mild, hardly existing buzz allows. Italian consumers can enjoy cannabis light in the form of pasta, olive oil and ice cream, as well as buds.

Ultra-low doses: when the dosage becomes very low

While microdosing and cannabis lite are used by consumers, researchers have also investigated the therapeutic potential of very low doses in the laboratory. Enter the lowest dose.

According to Dr. Stacia Woodcock, clinical pharmacist and director of education at the International Research Center for Cannabis and Health an extremely low dosage has its roots in the hormesis the concept that a compound at high and low doses has directly opposite effects can – also known as a two-phase dose dependency.

“Homeopathic medicine is based on this concept. Compounds that are toxic at standard doses or can produce undesirable effects are diluted by several orders of magnitude. At this point, the highly diluted form is used to prevent the same symptoms, ”said Woodcock.

“An easier way to explain this is to consider allergy shots. A large "dose" of environmental pollen that is introduced into the body causes terrible allergy symptoms, but a very dilute form of the same pollen injected into the body can actually help the body build an immune response to prevent these allergy symptoms from occurring . " she said.

In the case of cannabis, the extremely low dosage is several orders of magnitude smaller than a so-called microdose. "For example, if a microdose is considered 2 mg THC, an extremely low dose is 0.02 to 0.2 mg THC," said Woodcock. "However, these are not hard numbers because we have no human clinical trials that clearly define the boundaries between" dosage "," microdosing "or" extremely low dosage "."

Although it sounds like semantics, there are numerous indications that this is not the case. Most of the time, the key to optimizing weed experience is to gradually experiment with cans and note nuances until the perfect balance is achieved.

Studies on extremely low dosing

A number of studies have been conducted over the past decade to examine the effects of extremely low doses of THC. Previous results indicate that extremely low doses can change the plasticity of the brain and have long-term behavioral and developmental effects.

Several early studies indicated that extremely low doses of THC can cause mild cognitive impairment. In a 2007 study a single injection of an extremely low dose of THC (0.001 mg / kg) in mice had an adverse memory and learning impact that lasted up to four months. Similar results were reported in a 2010 study in which a single, extremely low dose caused behavioral deficits in mice that lasted up to five months.

According to the lead author of the 2010 study above, Dr. Haitham Amal, principal researcher at the Laboratory for Neuromics, Cell Signaling, and Translational Medicine at the Institute for Drug Research at the Hebrew University of Jerusalem. The potential for extremely low doses to achieve protective benefits outweighs the slight impairment.

"We found significant differences between the control dose and the treated group, which indicated that the extremely low dose can affect memory and spatial learning, but this effect is not serious, it is not serious harm," explained Amal. “In our follow-up, we used this extremely low dose, which has a specific molecular mechanism that differs from a high dose, to determine if it can protect mice from epileptic seizures and mechanical head injuries. We carried out these experiments and found that the extremely low dose gives a protective value in mouse models. "

According to Amal, the extremely low dose consists of two phases. The benefits of the extremely low dose in treating diseases overcome the disadvantages or sensitive damage that the extremely low dose can cause.

In addition, a subsequent animal study from 2014 showed that extremely low doses of THC can protect the brain from cognitive damage caused by neuroinflammation. The authors report that extremely low doses could potentially be used to treat neuroinflammatory conditions, including neurodegenerative diseases.

For Dr. Amal can support long-term, extremely low dosing for people suffering from neurological attacks due to diseases such as Alzheimer's, multiple sclerosis, autism spectrum disorder and Parkinson's. "My work dealt with a single administration of extremely low doses, so I'm assuming a hypothesis here," said Amal. "While chronic extremely low doses adversely affect memory, spatial learning, and biochemical changes, I think long-term use of low doses may be beneficial in treating these neurological disorders."

Amal's hypothesis was verified in a review from 2019 by the expert Dr. Yosef Sarne confirmed. Sarne reports that extremely low doses of THC have been shown to save cognitive function in models of mouse brain injury, including seizures, hypoxia, anesthesia, neurotoxicity and neuroinflammation. The anti-inflammatory properties of THC also help combat cognitive decline in neurodegenerative diseases and slow the age-related decline.

The protective effects caused by extremely low THC doses were not limited to the brain, but were also found in the kidneys, liver and heart.

Ultra-low dosage for beginners

If you are curious to try an extremely low dose yourself, in the above study Sarne recommends a human dose of 0.0002 mg / kg, which corresponds to 70 kg for a person of approximately 0.014 mg (or 14 micrograms) . This dose is 100 times lower than the standard threshold (1-2 mg THC) when the intoxicating effects of THC start to work.

Woodcock recommends tinctures and oral solutions if you want to experiment with extremely low doses. "They are easy to dilute and measure to give the dose accurately. As a clinician, I would only recommend using cannabis products from a legal source that is regulated and tested to ensure the accuracy of the dose used."

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Emma Stone is a New Zealand journalist specializing in cannabis, health and wellbeing. She has a Ph.D. in sociology and has worked as a researcher and lecturer, but above all loves being a writer. She would love to spend her days writing, reading, hiking, eating and swimming.